3466-81-7
- Product Name：2-Phenylpiperidinehydrochloride
- Molecular Formula：
- Purity：99%
- Molecular Weight：197.708
Product Details;
CasNo： 3466-81-7
Factory Supply 2-Phenylpiperidinehydrochloride, Offer 3466-81-7 with Lowest Price
- Molecular Formula:C11H15N*ClH
- Molecular Weight:197.708
2-Phenylpiperidinehydrochloride (Cas 3466-81-7) Usage
| Description | 2-Phenylpiperidine hydrochloride is a product of an intramolecular reaction. |
|
Uses |
2-Phenylpiperidine hydrochloride is a diastereoselective, intramolecular reaction product of β-unsaturated ketones and piperidines. |
3466-81-7 Relevant articles
Removal of the pyridine directing group from α-substituted N-(pyridin-2-yl)piperidines obtained via directed Ru-catalyzed sp3 C-H functionalization
Smout, Veerle,Peschiulli, Aldo,Verbeeck, Stefan,Mitchell, Emily A.,Herrebout, Wouter,Bultinck, Patrick,Vande Velde, Christophe M. L.,Berthelot, Didier,Meerpoel, Lieven,Maes, Bert U. W.
, p. 9803 - 9814 (2013)
Two strategies, "hydrogenation-hydride r...
A novel inhibitor of inducible NOS dimerization protects against cytokine-induced rat beta cell dysfunction
Zhong, Linlin,Tran, Tuan,Baguley, Tyler D,Lee, Sang Jun,Henke, Adam,To, Andrew,Li, Sijia,Yu, Shan,Grieco, Fabio A,Roland, Jason,Schultz, Peter G,Eizirik, Decio L,Rogers, Nikki,Chartterjee, Arnab K,Tremblay, Matthew S,Shen, Weijun
, p. 3470 - 3485 (2018/08/03)
Background and Purpose: Beta cell apopto...
3466-81-7 Process route
-
- 1261144-92-6
2-phenyl-1-(pyridin-2-yl)piperidine
-
- 3466-81-7,155106-18-6
2-phenylpiperidine hydrochloride
Conditions
| Conditions | Yield |
|---|---|
|
2-phenyl-1-(pyridin-2-yl)piperidine; With methyl trifluoromethanesulfonate; In acetonitrile; at 0 - 20 ℃; for 0.1h; Inert atmosphere;
With sodium tetrahydroborate; In methanol; acetonitrile; at 0 ℃; for 0.25h; Inert atmosphere;
With hydrogenchloride; In methanol; water; acetonitrile; for 0.0166667h; Inert atmosphere;
|
62% |
-
- 75844-69-8
t-butyl piperidinecarboxylate
-
- 3466-81-7,155106-18-6
2-phenylpiperidine hydrochloride
Conditions
| Conditions | Yield |
|---|---|
|
Multi-step reaction with 2 steps
1.1: sec.-butyllithium; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran / 3 h / -78 °C
1.2: -78 - 20 °C
1.3: 15 h
2.1: hydrogenchloride / dichloromethane / 5 h / 20 °C
With hydrogenchloride; N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In tetrahydrofuran; dichloromethane;
|
3466-81-7 Upstream products
-
1261144-92-6
2-phenyl-1-(pyridin-2-yl)piperidine
-
75844-69-8
t-butyl piperidinecarboxylate
-
108-86-1
bromobenzene
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