75143-89-4
- Product Name：3-Isobutylglutaric acid
- Molecular Formula：C9H16O4
- Purity：99%
- Molecular Weight：188.224
Product Details;
CasNo： 75143-89-4
Molecular Formula： C9H16O4
Export Chinese Manufacturer Supply 3-Isobutylglutaric acid 75143-89-4 Fast Delivery
- Molecular Formula:C9H16O4
- Molecular Weight:188.224
- Vapor Pressure:0mmHg at 25°C
- Melting Point:47 °C
- Refractive Index:1.472
- Boiling Point:326.197 °C at 760 mmHg
- PKA:4.19±0.10(Predicted)
- Flash Point:165.289 °C
- PSA：74.60000
- Density:1.126 g/cm3
- LogP:1.59810
3-isobutylglutaric acid(Cas 75143-89-4) Usage
|
Chemical Properties |
Pale Brown Solid |
|
Uses |
An impurity of Pregabalin (P704800) with anticonvulsant properties. |
|
Application |
3-Butylglutaric acid is an intermediate in the synthesis of pregabalin.Pregabalin is approved by the United States Food and Drug Administration (FDA) to treat neuropathic pain associated with diabetic peripheral neuropathy, spinal cord injury, and postherpetic neuralgia. Pregabalin is FDA-approved for the treatment of fibromyalgia. Pregabalin also has FDA approval as adjunctive therapy for partial-onset seizures in adults with epilepsy. |
InChI:InChI=1/C9H16O4/c1-6(2)3-7(4-8(10)11)5-9(12)13/h6-7H,3-5H2,1-2H3,(H,10,11)(H,12,13)
75143-89-4 Relevant articles
Development of a new synthesis approach for S-pregabalin by optimizing the preparation stages
Mansoori, Arsalan,Zahednezhad, Fahimeh,Bavili Tabrizi, Ahad,Shahbazi Mojarrad, Javid
, p. 89 - 101 (2019/09/13)
In the present study, we aimed to optimi...
Preparation method and application of high-purity dimethyl 3-isobutylglutarate
-
Paragraph 0124; 0127; 0133; 0135; 0171-0172, (2019/12/02)
The invention provides a preparation met...
Method for preparing 3-isobutylglutaric acid
-
, (2019/10/04)
The invention discloses a method for pre...
Method for synthesizing optically pure (R)-3-carbamoymethyl-5-methylhexanoic acid
-
Paragraph 0019; 0021; 0024; 0028; 0030, (2019/09/14)
The invention relates to the technical f...
75143-89-4 Process route
-
-
868-52-0
2?cyano?5?methylhex?2?enoic acid methyl ester
-
-
105-53-3
diethyl malonate
-
-
75143-89-4
5-methyl-3-carboxymethylhexanoic acid
| Conditions | Yield |
|---|---|
|
2?cyano?5?methylhex?2?enoic acid methyl ester; diethyl malonate;
With
piperidine;
at 55 ℃;
for 2h;
With
hydrogenchloride;
In
water;
at 100 - 120 ℃;
for 72h;
|
85% |
-
-
185815-56-9
2,4-dicyano-3-isobutylglutaramide
-
-
75143-89-4
5-methyl-3-carboxymethylhexanoic acid
| Conditions | Yield |
|---|---|
|
With
sulfuric acid;
for 12h;
Reflux;
|
99.4% |
|
With
hydrogenchloride; water;
at 140 ℃;
for 30h;
pH=1 - 2;
Temperature;
Reagent/catalyst;
|
85% |
75143-89-4 Upstream products
-
141-82-2
malonic acid
-
590-86-3
isovaleraldehyde
-
102710-09-8
2-isobutyl-propane-1,1,3,3-tetracarboxylic acid tetraethyl ester
-
392669-46-4
C17H24O8
75143-89-4 Downstream products
-
185815-59-2
3-isobutylglutaric anhydride
-
181289-15-6
(±)?3?(carbamoylmethyl)?5?methylhexanoic acid
-
148553-50-8
pregabilin
-
181289-33-8
(3R)‐3‐(carbamoylmethyl)‐5‐methylhexanoic acid
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