89213-87-6
- Product Name：Carperitide
- Molecular Formula：C127H203N45O39S3
- Purity：99%
- Molecular Weight：3080.48
Product Details;
CasNo： 89213-87-6
Molecular Formula： C127H203N45O39S3
Factory Supply High Purity Carperitide 89213-87-6 Reasonable Price
- Molecular Formula:C127H203N45O39S3
- Molecular Weight:3080.48
- Refractive Index:1.688
- PSA：1479.28000
- Density:1.55 g/cm3
- LogP:-2.10540
ANP 1-28, HUMAN(Cas 89213-87-6) Usage
|
Description |
Carperitide is the α-human atrial natriuretic peptide (α-hANP) produced by recombinant technology. It was introduced in Japan as a treatment for acute congestive heart failure (CHF). In dogs with CHF, carperitide significantly reduced the elevated left ventricular end-diastolic pressure and the index of myocardial oxygen consumption (systolic blood pressure x heart rate). In a clinical trial, carperitide was effective in improving hemodynamics and symptoms in 60% of patients with acute CHF. Carperitide was reported to be well tolerated with no significant adverse effects clinically. A beneficial effect on hemodynamics has been reported in chronic heart failure patients. Carperitide is also in clinical trials for maintenance of blood pressure during surgical operations. |
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Originator |
Suntory (Japan) |
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Uses |
Treatment of decompensated congestive heart failure. |
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Brand name |
Daiichi Suntory, Japan. |
InChI:InChI=1/C127H203N45O39S3/c1-9-64(6)99-121(209)150-52-94(182)151-65(7)100(188)155-76(34-35-91(129)179)109(197)167-85(56-174)104(192)149-53-96(184)153-78(43-62(2)3)102(190)148-54-97(185)154-89(119(207)164-82(48-92(130)180)114(202)169-86(57-175)116(204)163-81(46-67-23-14-11-15-24-67)113(201)158-73(27-18-39-143-125(135)136)107(195)166-84(122(210)211)47-68-30-32-69(178)33-31-68)60-213-214-61-90(171-118(206)88(59-177)170-117(205)87(58-176)168-108(196)74(28-19-40-144-126(137)138)156-106(194)72(26-17-38-142-124(133)134)157-112(200)79(44-63(4)5)161-101(189)70(128)55-173)120(208)162-80(45-66-21-12-10-13-22-66)103(191)147-50-93(181)146-51-95(183)152-71(25-16-37-141-123(131)132)105(193)160-77(36-42-212-8)110(198)165-83(49-98(186)187)115(203)159-75(111(199)172-99)29-20-41-145-127(139)140/h10-15,21-24,30-33,62-65,70-90,99,173-178H,9,16-20,25-29,34-61,128H2,1-8H3,(H2,129,179)(H2,130,180)(H,146,181)(H,147,191)(H,148,190)(H,149,192)(H,150,209)(H,151,182)(H,152,183)(H,153,184)(H,154,185)(H,155,188)(H,156,194)(H,157,200)(H,158,
89213-87-6 Relevant articles
One-Pot/Sequential Native Chemical Ligation Using Photocaged Crypto-thioester
Aihara, Keisuke,Yamaoka, Kosuke,Naruse, Naoto,Inokuma, Tsubasa,Shigenaga, Akira,Otaka, Akira
, p. 596 - 599 (2016)
A practical and efficient methodology fo...
Selective disulfidation reagent using nitrogen-containing compound and method for producing disulfide-containing compound
-
Page/Page column 28-30, (2020/12/02)
The present invention provides a means c...
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In this paper, a new disulfide-forming a...
89213-87-6 Process route
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91917-63-4
atrial natriuretic peptide
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89213-87-6
human atrial natriuretic peptide
| Conditions | Yield |
|---|---|
|
With
methyl 6-(methoxythio)-5-nitronicotinate;
In
water; acetonitrile;
at 20 ℃;
for 24h;
pH=6;
|
50% |
|
With
methyl 6-(methoxythio)-5-nitronicotinate;
In
water; acetonitrile;
at 20 ℃;
for 24h;
Time;
|
50% |
|
In
aq. phosphate buffer; dimethyl sulfoxide;
at 37 ℃;
for 2.5h;
pH=7.6;
|
26% |
89213-87-6 Upstream products
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91917-63-4
atrial natriuretic peptide
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