84379-13-5
- Product Name：BRETAZENIL
- Molecular Formula：C19H20BrN3O3
- Purity：99%
- Molecular Weight：418.29
Product Details;
CasNo： 84379-13-5
Molecular Formula： C19H20BrN3O3
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What is the Bretazenil ?
Bretazenil is , while it's Molecular Formula is C19H20BrN3O3. Anti-anxiety agent.Bretazenil potentiated GABA responses on α4β3γ2 cells.Bretazenil is a partial benzodiazepine receptor agonist. Benzodiazepines, mainly diazepam, are commonly used as anticonvulsants in the treatment of organophosphate casualties. Bretazenil has been used to determine non-specific binding due to its affinity to bind to a variety of γ-aminobutyric acid type A (GABAA) receptor subtypes (α1-3;5). It has also been used as a GABAA receptor partial agonist in the subcutaneous Alzet minipumps to treat obese agouti related protein (AgRP) ablated and lean naive mice to study its effect on them.
What is the CAS number for Bretazenil ?
The CAS number of Bretazenil is 84379-13-5.
More information of Bretazenil 84379-13-5 are:
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Synonyms |
9H-Imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylicacid, 8-bromo-11,12,13,13a-tetrahydro-9-oxo-, 1,1-dimethylethyl ester, (S)-;9H-Imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid, 8-bromo-11,12,13,13a-tetrahydro-9-oxo-, 1,1-dimethylethyl ester, (13aS)-;Ro 16-6028;Ro 16-6028/000;tert-Butyl (13aS)-8-bromo-9-oxo-11,12,13,13a-tetrahydro-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylate;8-Bromo-7-oxo-3b,4,5,6-tetrahydro-7H-2,6a,11b-triaza-benzo[g]cyclopenta[e]azulene-3-carboxylic acid tert-butyl ester; |
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CAS Number |
84379-13-5 |
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Molecular Formula |
C19H20BrN3O3 |
|
Molecular Weight |
418.29 |
|
Density |
1.56 g/cm3 |
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Boiling Point |
594.3 °C at 760 mmHg |
|
Flash Point |
313.2 °C |
|
PSA |
64.43000 |
|
LogP |
3.81870 |
|
Pka |
0.78±0.20(Predicted) |
What is Bretazenil (84379-13-5) used for?
Bretazenil is an imidazobenzodiazepine partial agonist and a potent anxiolytic. It is rapidly absorbed and has a half-life of 2.5 hours. Animal work has shown that, even after long-term administration of bretazenil, there are no changes in GABA receptor binding or function, and tolerance does not occur. Studies in humans have also suggested that bretazenil has a low abuse potential (Sellers et al. 1991). In terms of clinical effects, bretazenil has demonstrated anxiolytic efficacy in both generalized anxiety disorder and panic disorder (Katschnig et al. 1991), but no controlled study has compared bretazenil with a classic full agonist.
InChI:InChI=1/C19H20BrN3O3/c1-19(2,3)26-18(25)15-16-13-8-5-9-22(13)17(24)14-11(20)6-4-7-12(14)23(16)10-21-15/h4,6-7,10,13H,5,8-9H2,1-3H3/t13-/m0/s1
Articles related to Bretazenil:
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Article |
Source |
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Synthesis of 123I-labelled analogues of imidazobenzodiazepine receptor ligands |
Katsifis, Andrew G.,McPhee, Meredith E.,Mattner, Filomena,Ridley, Damon D. , p. 1061 - 1069 (2007/10/03) |
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