What is the 7-(4,7-diazaspiro[2.5]octan-7-yl)-2-(2,8-dimethylimidazo[l,2- b]pyridazin-6-yl)-4H-pyrido[l,2-a]pyrimidin-4-one?

7-(4,7-diazaspiro[2.5]octan-7-yl)-2-(2,8-dimethylimidazo[l,2- b]pyridazin-6-yl)-4H-pyrido[l,2-a]pyrimidin-4-one is , while it's Molecular Formula is C 22 H 23 N 7 O. Risdiplam is used in preparation of Imidazopyridazinyl Pyridopyrimidinones for treating spinal muscular atrophy. Gene splicing modulator.

What is the CAS number for 7-(4,7-diazaspiro[2.5]octan-7-yl)-2-(2,8-dimethylimidazo[l,2- b]pyridazin-6-yl)-4H-pyrido[l,2-a]pyrimidin-4-one?

The CAS number of 7-(4,7-diazaspiro[2.5]octan-7-yl)-2-(2,8-dimethylimidazo[l,2- b]pyridazin-6-yl)-4H-pyrido[l,2-a]pyrimidin-4-one is 1825352-65-5.

What is 7-(4,7-diazaspiro[2.5]octan-7-yl)-2-(2,8-dimethylimidazo[l,2- b]pyridazin-6-yl)-4H-pyrido[l,2-a]pyrimidin-4-one (1825352-65-5) used for?

Risdiplam is a survival of motor neuron 2 (SMN2) splicing modifier.

What is the 7-(4,7-diazaspiro[2.5]octan-7-yl)-2-(2,8-dimethylimidazo[l,2- b]pyridazin-6-yl)-4H-pyrido[l,2-a]pyrimidin-4-one?

7-(4,7-diazaspiro[2.5]octan-7-yl)-2-(2,8-dimethylimidazo[l,2- b]pyridazin-6-yl)-4H-pyrido[l,2-a]pyrimidin-4-one is , while it's Molecular Formula is C 22 H 23 N 7 O. Risdiplam is used in preparation of Imidazopyridazinyl Pyridopyrimidinones for treating spinal muscular atrophy. Gene splicing modulator.

What is the CAS number for 7-(4,7-diazaspiro[2.5]octan-7-yl)-2-(2,8-dimethylimidazo[l,2- b]pyridazin-6-yl)-4H-pyrido[l,2-a]pyrimidin-4-one?

The CAS number of 7-(4,7-diazaspiro[2.5]octan-7-yl)-2-(2,8-dimethylimidazo[l,2- b]pyridazin-6-yl)-4H-pyrido[l,2-a]pyrimidin-4-one is 1825352-65-5.

What is 7-(4,7-diazaspiro[2.5]octan-7-yl)-2-(2,8-dimethylimidazo[l,2- b]pyridazin-6-yl)-4H-pyrido[l,2-a]pyrimidin-4-one (1825352-65-5) used for?

Risdiplam is a survival of motor neuron 2 (SMN2) splicing modifier.

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1825352-65-5

Product Name：Risdiplam
Molecular Formula：
Purity：99%
Molecular Weight：401.471

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Product Details;

CasNo： 1825352-65-5

Buy Reliable Quality High Purity 99% Risdiplam 1825352-65-5 Safe Delivery

Molecular Formula:C₂₂H₂₃N₇O
Molecular Weight:401.471
Density:1.50±0.1 g/cm3(Predicted)

1825352-65-5 Relevant articles

PROCESS FOR THE PREPRATION OF 7-(4,7-DIAZASPIRO[2.5]OCTAN-7-YL)-2-(2,8-DIMETHYLIMIDAZO[1,2-B]PYRIDAZIN-6-YL)PYRIDO[1,2-A]PYRIMIDIN-4-ONE DERIVATIVES

-

, (2019/04/16)

The present invention relates to a proce...

COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY

-

, (2019/10/29)

The present invention provides compounds...

Discovery of Risdiplam, a Selective Survival of Motor Neuron-2 (SMN2) Gene Splicing Modifier for the Treatment of Spinal Muscular Atrophy (SMA)

Ratni, Hasane,Ebeling, Martin,Baird, John,Bendels, Stefanie,Bylund, Johan,Chen, Karen S.,Denk, Nora,Feng, Zhihua,Green, Luke,Guerard, Melanie,Jablonski, Philippe,Jacobsen, Bjoern,Khwaja, Omar,Kletzl, Heidemarie,Ko, Chien-Ping,Kustermann, Stefan,Marquet, Anne,Metzger, Friedrich,Mueller, Barbara,Naryshkin, Nikolai A.,Paushkin, Sergey V.,Pinard, Emmanuel,Poirier, Agnès,Reutlinger, Michael,Weetall, Marla,Zeller, Andreas,Zhao, Xin,Mueller, Lutz

, p. 6501 - 6517 (2018/08/17)

SMA is an inherited disease that leads t...

COMPOUNDS FOR TREATING AMYOTROPHIC LATERAL SCLEROSIS

-

, (2017/06/01)

The present invention provides compounds...

1825352-65-5 Process route

: 17412-23-6
6-chloro-2,8-dimethyl-imidazo[1,2-b]pyridazine

: 1825352-65-5
7-(4,7-diazaspiro[2.5]octan-7-yl)-2-(2,8-dimethylimidazo[l,2- b]pyridazin-6-yl)-4H-pyrido[l,2-a]pyrimidin-4-one

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)CH₂Cl₂; potassium acetate / 1,4-dioxane / 15 h / 110 °C / Inert atmosphere 2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; acetonitrile / 6 h / 100 °C / Inert atmosphere 3: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 48 h / 130 °C / Sealed tube With* tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; water; dimethyl sulfoxide; acetonitrile; 2: \|Suzuki Coupling;
Multi-step reaction with 3 steps 1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)CH₂Cl₂ / 1,4-dioxane / 15 h / 110 °C / Inert atmosphere 2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / acetonitrile / 6 h / 100 °C 3: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 48 h / 130 °C / Sealed tube With* tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dimethyl sulfoxide; acetonitrile; 2: \|Suzuki Coupling;
Multi-step reaction with 3 steps 1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)CH₂Cl₂ / 1,4-dioxane / 15 h / 110 °C / Inert atmosphere 2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / acetonitrile; water / 6 h / 100 °C / Inert atmosphere 3: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 48 h / 130 °C / Sealed tube With* tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; water; dimethyl sulfoxide; acetonitrile;
Multi-step reaction with 3 steps 1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)CH₂Cl₂ / 1,4-dioxane / 15 h / 110 °C / Inert atmosphere 2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; acetonitrile / 6 h / 100 °C / Inert atmosphere 3: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 48 h / 130 °C / Inert atmosphere With* tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; water; dimethyl sulfoxide; acetonitrile; 2: \|Suzuki Coupling;
Multi-step reaction with 3 steps 1.1: potassium acetate / acetonitrile / 0.5 h / Reflux 1.2: 4 h / Reflux 2.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / acetonitrile; water / 3 h / Reflux 3.1: hydrogenchloride / 1-Propyl acetate; propan-1-ol / 15 h / 75 °C With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In propan-1-ol; 1-Propyl acetate; water; acetonitrile;
Multi-step reaction with 3 steps 1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)CH₂Cl₂; potassium acetate / 1,4-dioxane / 15 h / 110 °C / Inert atmosphere 2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / acetonitrile; water / 6 h / 100 °C 3: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 48 h / 130 °C / Sealed tube With* tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; water; dimethyl sulfoxide; acetonitrile;

: 2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-7-fluoro-pyrido[1,2-a]pyrimidin-4-one

: 145122-56-1
4,7-diazaspiro<2,5>octane dihydrochloride

: 1825352-65-5
7-(4,7-diazaspiro[2.5]octan-7-yl)-2-(2,8-dimethylimidazo[l,2- b]pyridazin-6-yl)-4H-pyrido[l,2-a]pyrimidin-4-one

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 130 ℃; for 48h; Sealed tube;	18%
With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 130 ℃; for 48h; Sealed tube;	18%
With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 130 ℃; for 48h; Sealed tube;	18%
With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 130 ℃; for 48h; Inert atmosphere;	18%
With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 130 ℃; for 48h; Sealed tube;	18%

1825352-65-5 Upstream products

19064-64-3
3,6-dichloro-4-methylpyridazine
17412-23-6
6-chloro-2,8-dimethyl-imidazo[1,2-b]pyridazine
1825352-86-0
2,8-dimethyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-b]pyridazine
145122-56-1
4,7-diazaspiro<2,5>octane dihydrochloride

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Conditions	Yield
Multi-step reaction with 3 steps 1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)CH₂Cl₂; potassium acetate / 1,4-dioxane / 15 h / 110 °C / Inert atmosphere 2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; acetonitrile / 6 h / 100 °C / Inert atmosphere 3: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 48 h / 130 °C / Sealed tube With* tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; water; dimethyl sulfoxide; acetonitrile; 2: \|Suzuki Coupling;
Multi-step reaction with 3 steps 1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)CH₂Cl₂ / 1,4-dioxane / 15 h / 110 °C / Inert atmosphere 2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / acetonitrile / 6 h / 100 °C 3: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 48 h / 130 °C / Sealed tube With* tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dimethyl sulfoxide; acetonitrile; 2: \|Suzuki Coupling;
Multi-step reaction with 3 steps 1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)CH₂Cl₂ / 1,4-dioxane / 15 h / 110 °C / Inert atmosphere 2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / acetonitrile; water / 6 h / 100 °C / Inert atmosphere 3: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 48 h / 130 °C / Sealed tube With* tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; water; dimethyl sulfoxide; acetonitrile;
Multi-step reaction with 3 steps 1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)CH₂Cl₂ / 1,4-dioxane / 15 h / 110 °C / Inert atmosphere 2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; acetonitrile / 6 h / 100 °C / Inert atmosphere 3: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 48 h / 130 °C / Inert atmosphere With* tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; water; dimethyl sulfoxide; acetonitrile; 2: \|Suzuki Coupling;
Multi-step reaction with 3 steps 1.1: potassium acetate / acetonitrile / 0.5 h / Reflux 1.2: 4 h / Reflux 2.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / acetonitrile; water / 3 h / Reflux 3.1: hydrogenchloride / 1-Propyl acetate; propan-1-ol / 15 h / 75 °C With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In propan-1-ol; 1-Propyl acetate; water; acetonitrile;
Multi-step reaction with 3 steps 1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)CH₂Cl₂; potassium acetate / 1,4-dioxane / 15 h / 110 °C / Inert atmosphere 2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / acetonitrile; water / 6 h / 100 °C 3: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 48 h / 130 °C / Sealed tube With* tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; water; dimethyl sulfoxide; acetonitrile;