736992-21-5
- Product Name：Elamipretide
- Molecular Formula：C32H49N9O5
- Purity：99%
- Molecular Weight：639.798
Product Details;
CasNo： 736992-21-5
Molecular Formula： C32H49N9O5
Buy High Grade Reliable Quality Elamipretide 736992-21-5 On Stock
- Molecular Formula:C32H49N9O5
- Molecular Weight:639.798
- PKA:10.10±0.25(Predicted)
- PSA：276.02000
- Density:1.34±0.1 g/cm3(Predicted)
- LogP:5.71560
Elamipretide (Cas 736992-21-5) Usage
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Description |
Elamipretide is a new tetrapeptide that targets and stabilizes mitochondrial cardiolipin. Elamipretide is a small mitochondrially-targeted tetrapeptide that appears to reduce the production of toxic reactive oxygen species and stabilize cardiolipin. |
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Uses |
Elamipretide is an investigational drug being developed to treat mitochondrial diseases, yet to be approved by the FDA, but has received orphan drug status. |
736992-21-5 Relevant articles
A novel mitochondria-targeting tetrapeptide for subcellular delivery of nanoparticles
Sun, Yanhui,Zhan, Aiyan,Zhou, Shuang,Kuang, Xiao,Shen, Hongyan,Liu, Hongzhuo,Xu, Youjun
, p. 1435 - 1439 (2019)
Mitochondrial dysfunction is associated ...
Methods and Compositions for Delivery of Biotin to Mitochondria
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Page/Page column 22, (2022/03/19)
Certain exemplary embodiments are direct...
PROCESSES FOR PREPARING PHARMACEUTICALLY RELEVANT PEPTIDES
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Paragraph 0170, (2016/09/26)
The present technology provides methods ...
TETRAPEPTIDE COMPOUND AND METHOD FOR PRODUCING SAME
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, (2016/10/04)
The present invention is to provide a me...
736992-21-5 Process route
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Boc-D-Arg-DMT-Lys(Boc)-Phe-NH2
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- 736992-21-5
D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide
| Conditions | Yield |
|---|---|
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With acetyl chloride; In isopropyl alcohol; at 0 - 40 ℃; for 1.25h; Inert atmosphere;
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88% |
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N2-[(benzyloxy)carbonyl]-N5-[{[(benzyloxy)carbonyl]amino}{[(benzyloxy)carbonyl]imino}methyl]-D-ornithyl-2,6-dimethyl-L-tyrosyl-N6-{[(2-chlorobenzyl)oxy]carbonyl}-L-lysyl-L-phenylalaninamide
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- 736992-21-5
D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide
| Conditions | Yield |
|---|---|
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With palladium 10% on activated carbon; hydrogen; acetic acid; In methanol; at 50 ℃; for 4h;
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736992-21-5 Upstream products
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65864-22-4
(S)-2-amino-3-phenylpropionamide hydrochloride
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17337-86-9
H-Lys(Boc)Phe-NH2
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2389-60-8
Z-Lys(Boc)-OH
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17337-68-7
Nα-Benzyloxycarbonyl-lysyl(Nε-t-butyloxycarbonyl)phenylalaninamide
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